Why is Comtan prescribed?

Comtan, with the generic name Entacapone, is used together with other medications (Levodopa and Carbidopa) to manage the end-of-dose (wearing-off of the effect of the drug) symptoms of Parkinson’s disease.

What does it do?

Entacapone, classified under Catechol-O-Methyltransferase (COMT) inhibitors, allows the effects of levodopa and carbidopa to reach the brain more efficiently to facilitate their effects and help prevent the symptoms of Parkinson’s disease such as stiffness, tremors, spasms, or uncontrollable movements.

How should I take it?

Comtan is currently available as a 200mg tablet taken whole (not split, chewed, or crushed) by mouth with or without food.

The dosage strength and frequency depend on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before taking Comtan?

Comtan is known to cause drowsiness. Avoid driving or operating heavy machinery while taking this medication. Avoid the intake of alcohol as this could exacerbate drowsiness.

Inform your doctor about all the medications you are taking. Discuss your current and previous medical history and any allergic reactions to Comtan, or any other ingredients included in the manufacture of this medication.

Inform your doctor if you had any form of surgery or if you are planning to get one.

For the drug label information of Comtan, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Uncontrollable movements
• Nausea
• Abdominal pain
• Drowsiness
• Diarrhea

Serious side effects may include:
• Itching, hives, or rash
• Swelling on any part of the face
• Hoarseness
• Difficulty breathing or swallowing
• Hallucinations
• Weakness
• High fever
• Muscle stiffness

Is it safe to take it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Comtan with any of the following medications:

• Abilify
• Azilect
• Baclofen
• Bromocriptine
• Butalbital
• Cannabidiol
• Cannabis
• Carbamazepine
• Celexa
• Clozapine
• Coumadin
• Diazepam
• Doxepin
• Effexor
• Epinephrine
• Ethanol
• Ferric citrate
• Fluoxetine
• Furazolidone
• Geodon
• Haloperidol
• Hydrocodone
• Isocarboxazid
• Kava
• Lexapro
• Linezolid
• Methylene blue
• Morphine
• Multivitamin with iron
• Multivitamin with iron and fluoride
• Multivitamin with minerals
• Multivitamin, prenatal
• Nalbuphine
• Ozanimod
• Phenelzine
• Pristiq
• Procarbazine
• Propoxyphene
• Risperdal
• Sodium oxybate
• Thalidomide
• Tranylcypromine
• Valproic acid
• Zyrtec

Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Keep Comtan in its original packaging in a clean environment away from excessive heat and moisture. Keep out of reach of children.

What action should I take in case of overdose?

Immediately call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

Entacapone is contraindicated for use in pregnant women, women trying to get pregnant, or are breastfeeding. Hence, the potential risks and benefits of using Comtan in pregnant or breastfeeding infants should be carefully considered.

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