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Contrave (Naltrexone / Bupropion) is prescribed to help manage weight gain in patients who have weight problems or obesity related to medical issues. It is normally used along with a low-calorie diet and adequate exercise to lose weight and maintain it.

What does it do?

Contrave contains Naltrexone, which belongs to a drug class known as opiate antagonists and bupropion, which belongs to a drug class antidepressant that may help reinstate the balance of certain natural chemicals (neurotransmitters) in the brain. It works in the hypothalamus, the central thermostat of the brain that controls body temperature, appetite, and how the body burns energy to manage food cravings.

How should I take it?

The dosing regimen as prescribed by the healthcare provider should be strictly followed as it is patient specific. This is usually taken orally twice a day with a low-fat diet. Do not crush, split, or chew, it should be swallowed whole with plenty of water. It is preferably taken the same time each day for the maximum benefit.

What if I missed a dose?

If you missed a dose, take it immediately upon recall. Otherwise, you may skip a dose (if almost time for the next dose) and take the next one as per your regular dosing schedule. Do not take a double dose to replace the missed dosage.

What are the special precautions before taking Contrave?

Before taking this medication, please take note of the following:

• Inform your doctor if you have an allergy to this medication or to any medication.
• Inform your doctor if you are trying or planning to get pregnant as this medication may pose a risk to the unborn baby.
• Inform your doctor of any medical problem, particularly of heart disease (heart attack or congestive heart failure), mental or mood disorder (suicidal thoughts, bipolar disorder), high blood pressure, diabetes, kidney disease, liver disease, seizure conditions, seizure, and eating disorder.
• This may cause dizziness and may affect the patient's capability to drive a car or operate machinery, hence, proper caution should be practiced.

Does it have any side effects?

Contrave may cause the following side effects may include:
• Nausea
• Vomiting
• Constipation
• Stomach pain
• Headache
• Trouble sleeping
• Dizziness
• Flushing
• Sweating (increased)
• Strange taste in the mouth
• Dry mouth

Serious side effects may include:
• Mood changes
• Irregular heartbeat
• Severe headache
• Fainting
• Chest pain
• Ringing in the ears
• Tremors

Rare side effects may include:
• Seizure
• Allergic reaction
• Liver disease

Other patients may experience adverse effects not mentioned above. If symptoms are persistent or become worse, immediately stop taking the medication. Call your doctor or ambulance for professional medical assistance.

Is it safe to take it with another drug?

Inform your doctor or pharmacist if you are planning to take or taking the following (possible drug interaction may occur if they are taken together):

• Acyclovirc
• Amitriptyline
• Amphetamine
• Ampicillin
• Carbimazole
• Atropine
• Azelastine
• Buclizine
• Cimetidine
• Carvedilol
• Clopidogrel
• Cloxacillin
• Desvenlafaxine
• Diphenhydramine
• Ebastine
• Fentanyl
• Levofloxacin
• Lidocaine
• Methimazole
• Morphine


Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

This must be stored at room temperature. Keep away from direct light and moisture. Do not keep it in the bathroom. Keep out of reach of children and pets.

What action should I take in case of an overdose?

Call poison control in case of overdose. If the patient has overdosed and experienced serious symptoms below, please call emergency services immediately.

Symptoms of overdose:

• Slow breathing
• Loss of consciousness
• Pale/blue/cold skin
• Small pupil (pinhead size)

Is it safe for pregnant or breastfeeding women?

Use of Contrave during pregnancy is not recommended as weight loss during pregnancy may harm the unborn baby.

For breastfeeding women, consult your healthcare provider before taking this medication as the medicine may pass via breastmilk and may result in undesirable effects on the infant.

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