Why is Crinone prescribed?

Progesterone (Crinone) gel is prescribed for the treatment of secondary amenorrhea (a condition when women do not have regular menstrual periods). It is also used to supply or replace progesterone as part of an Assisted Reproductive Technology (ART) treatment for women having difficulties or are not able to get pregnant due to the absence of progesterone.

What does it do?

Progesterone is a hormone in women responsible for ovulation and menstruation. It also alters the uterus lining to make implantation of the fertilized egg easier, thus helping the body to maintain the pregnancy.

How should I apply it?

Crinone and its generic equivalents are currently available as an 8% gel. It is for vaginal use only.

Using the applicator provided, insert the medication directly into the vagina then throw it away. The applicator is disposable and should only be used once. Follow the instructions that come with the medication and consult your doctor or pharmacist for any concerns you may have.

The dosage strength depends on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only use this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if used properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, apply it immediately and adjust the time of your next dose depending on your doctor’s advice. Never apply two doses at the same time just to make up for your missed dose.

What are the special precautions before applying Crinone?

Inform your doctor about all the medications you are taking, your current and previous medical history, and any allergic reactions to Crinone or any other ingredients included in the manufacture of this medication.

Taking Crinone can make you prone to developing blood clots, having a stroke, heart attack, or breast cancer. Consult your doctor regarding this possibility.

Inform your doctor if you become pregnant while using Crinone. Unless you are using it for infertility, you may need to use birth control methods to prevent pregnancy from occurring.

For the drug label information of Crinone, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Breast pain
• Confusion
• Constipation
• Diarrhea
• Dizziness
• Drowsiness
• Headache
• Mood swings
• Pain in the pelvic area
• Stomach pain
• Tiredness
• Vaginal itching, burning, or discharge

Serious side effects include:
• Chest pain
• Coughing up blood
• Difficulty breathing
• Lump in the breast
• Numbness on one side of the body
• Pain or burning sensation when urinating
• Pain or swelling in the leg
• Sleep problems
• Unusual vaginal bleeding
• Yellowing of the skin or eyes

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Crinone with any of the following medications:

• Acetohexamide
• Amaryl
• Banzel
• Biaxin
• Binimetinib
• Bosentan
• Butabarbital
• Canagliflozin
• Clotrimazole
• Colestipol
• Darunavir
• Diflucan
• Doxorubicin
• Edoxaban
• Efavirenz
• Elagolix
• Eliquis
• Emend
• Exenatide
• Felbamate
• Idarubicin
• Lamictal
• Letermovir
• Miglitol
• Mitoxantrone
• Multaq
• Mysoline
• Nafcillin
• Nizoral
• Questran
• Restasis
• Somatropin
• Sporanox
• Tolazamide
• Trileptal
• Ubrogepant
• Vemurafenib
• Venetoclax

Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Store Crinone in its container in a clean environment away from excessive heat and moisture. Keep out of reach of children.

What action should I take in case of overdose?

Immediately call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

Present data suggest that the use of Crinone in pregnant women has not established its developmental risks.

Data also shows that Crinone is excreted in human milk and may cause harmful effects to the breastfed infant. Hence, the potential risks and benefits of using Crinone in pregnant or breastfeeding women should be carefully considered.

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