Why is Depakote prescribed?

Divalproex Sodium (Depakote) is prescribed alone or in combination with other medication to treat maniac episodes associated with psychiatric disorders (bipolar disorder) and seizures. It is also being used as a prophylaxis of migraine headaches.

What does it do?

Depakote, a derivative of Valproic Acid, is an anticonvulsant drug that is primarily used in the treatment of convulsion, epilepsy and bipolar disorders. It is considered to be a mood stabilizer medication and its effect is being exerted by increasing the concentration of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, in the brain. An increase in the inhibitory action of GABA means an increased inhibitory activity

How should I use it?

Depakote is available as 125mg, 250mg and 500mg tablets. It is also available as Depakote ER in 500mg. Both are intended for oral administration. Each tablet should be taken as a whole and should not be crushed or chewed.

The dosage strength depends on every patient’s condition and the doctor’s prescription. It is strictly advised that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

Taking the dose properly at the scheduled time is needed to attain the desired effect of the drug. If you miss a dose, take it as soon as you remember. However, if it is near the time of the next dose, skip the missed dose and catch the next dose at the regular time. Do not take two doses just to make up for your missed dose.

What are the special precautions before using Depakote?

Before taking Depakote, tell your doctor or pharmacist if you have any allergies to food and to the drug itself as it may contain several inactive ingredients, which can cause allergic reactions or problems.

Inform your doctor about your past and current medical history and if you’ve had any past surgeries or if you’re planning to get one.

For the drug label information of Depakote, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Diarrhea
• Dizziness
• Drowsiness
• Hair loss
• Blurred vision
• Ringing of ears
• Change in menstrual period
• Tremors

Serious side effects include:
• Chest pain
• Easy bruising
• Unexplained bleeding
• Tachycardia/Bradycardia
• Uncontrolled eye movement (Nystagmus)
• Loss of consciousness

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Depakote with any of the following medications:

• Aspirin
• Coumadin
• Dilantin
• Doripenem
• Elavil
• Ethosuximide
• Imipenem
• Irinotecan
• Lamictal
• Mefloquine
• Nortriptyline
• Orlistat
• Phenelzine
• Rifadin
• Vorinostat
• Zidovudine

Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Store Depakote/Depakote ER in room temperature with a clean environment away from light and moisture. Keep away from children. Do not store in the bathroom.

What action should I take in case of overdose?

Immediately call an ambulance and seek immediate medical attention to prevent further complications.

Is it safe for pregnant or breastfeeding women?

Valproic Acid is not recommended to be used during pregnancy as it may risk the unborn baby for serious birth defects that affect the brain and spinal cord. Furthermore, it is contraindicated to be used as a prophylaxis to migraine headaches who are pregnant and in women of childbearing potential who are not using oral contraceptives.

Depakote also passes into breast milk. While there have been no reports of harm and/or danger to nursing infants, it is better to consult your doctor first before breastfeeding.

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