NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Endometrin prescribed?

Endometrin is used in fertility treatments as a component of Assisted Reproductive Technology (ART) for women who struggle to conceive due to insufficient natural progesterone in their body.

What does it do?

Endometrin is a vaginal insert that contains progesterone, a hormone essential for ovulation and menstruation in women. Progesterone alters the lining of the uterus, creating a more favorable environment for a fertilized egg to implant at the start of pregnancy. It also plays a key role in helping the body sustain the pregnancy.

How should I take it?

Endometrin is intended for vaginal use only. Remove the suppository from its wrapper. Using the applicator as instructed, insert the medication into the vagina as directed by your doctor, typically 2 or 3 times a day. If you become pregnant, continue using this medication for up to 10 weeks, or as advised by your doctor.

What if I missed a dose?

Take the missed dose as soon as you remember. If it’s nearly time for your next dose, skip the missed dose. Do not double dose.

What are the special precautions before taking Endometrin?

Inform your doctor about all the medications you are taking, your current and previous medical history.

• Abnormal vaginal bleeding
• Liver disease
• A history of blood clots, stroke, or circulation problems
• Breast or uterine cancer
• Recently had a tubal pregnancy or an incomplete or "missed" abortion

To ensure Endometrin is safe for you, inform your doctor if you have:

• Asthma
• Depression
• Migraines
• Kidney disease
• Seizures or epilepsy
• High blood pressure or congestive heart failure
• Risk factors for coronary artery disease, such as diabetes, lupus, high cholesterol, family history of coronary artery disease, smoking, or being overweight

Using Endometrin may increase your risk of blood clots, heart attack, stroke, or breast cancer. Discuss these risks with your doctor.

Does it have any side effects?

Seek emergency medical attention if you experience signs of an allergic reaction to Endometrin, such as hives, difficulty breathing, or swelling of your face or throat.

Common side effects may include:
• Cramps or pelvic pain
• Dizziness or tiredness
• Stomach pain or constipation
• Headache or feelings of nervousness or irritability
• Vaginal itching or discharge

Serious side effects may include:
• A breast lump
• Unusual vaginal bleeding
• Pain or burning during urination
• Symptoms of depression (such as mood changes)
• Signs of a heart attack, such as chest pain or pressure
• Symptoms of liver problems, including nausea or jaundice
• Sudden vision problems, severe headache, or pain behind the eyes
• Symptoms of a blood clot in the leg, such as pain
• Signs of a stroke, such as sudden numbness especially on one side of the body
• Symptoms of a blood clot in the lung, including chest pain or coughing up blood

This is not a complete list of side effects. Others may occur. Contact your doctor for advice regarding side effects.

Is it safe to take it with another drug?

Some drug interactions may cause serious or life-threatening reactions when administered together. Immediately inform your doctor if you are taking Endometrin with any of the following medications:

• Carbamazepine
• Rifampin
• Do not use with other vaginal anti fungal products.

Unless directed by your doctor, avoid using other vaginal products during treatment with this medication, as they may interfere with how well the drug is absorbed by your body.

How should I store it?

Store Endometrin at room temperature 20 - 25°C. Keep all medications out of reach of children and pets.

What action should I take in case of overdose?

This medication can be harmful if ingested. If someone overdoses and experiences severe symptoms like fainting or difficulty breathing, call emergency services immediately.

Is it safe for pregnant or breastfeeding women?

Endometrin may be used during pregnancy, but only under your doctor’s guidance. Be sure to discuss the potential risks and benefits with your doctor.

This medication can pass into breast milk. Consult your doctor before breastfeeding.

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