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Epiduo Forte Gel (Adapalene/Benzoyl Peroxide) is used for the topical treatment of acne (acne vulgaris) on the face, chest, and back, specifically for cases involving comedones like clogged hair follicles such as blackheads and whiteheads as well as multiple inflammatory papules and pustules (e.g., pimples).

What does it do?

Epiduo Forte should be used only if the acne has not responded to other treatments first. It combines two active ingredients, adapalene and benzoyl peroxide, which function in different yet complementary ways.

Adapalene is a topical retinoid that primarily works to normalize skin cell development, prevent pore blockage, and promote skin renewal.

Benzoyl peroxide has antibacterial properties that kill bacteria and also helps to soften and exfoliate the outer layer of the skin. Together, adapalene and benzoyl peroxide effectively reduce inflammation quickly.

How should I take it?

Epiduo Forte Gel should be applied once daily in the evening to all areas of the face and trunk affected by acne on a clean and dry skin. A thin layer of gel should be applied using your fingertips. Avoid the eyes, lips, and mucous membranes.

Do not apply to skin that is cut, scraped, sunburned, or affected by eczema. Apply sunscreen in the morning and moisturizer as needed.

What if I missed a dose?

Apply it as soon as you remember, but if it’s nearly time for your next dose, skip the missed dose and continue at the regular schedule. Do not apply extra amount on your next schedule.

What are the special precautions before taking Epiduo Forte Gel?

Inform your doctor about all the medications you are taking, your current and previous medical history.

Before taking this medication, please take note of the following:

• Avoid using waxing as a method of hair removal on skin that has been treated with Epiduo Forte Gel
• Avoid using other potentially irritating topical products, such as medicated or abrasive soaps and cleansers, and cosmetics with strong skin-drying effects, and products containing high concentrations of alcohol, astringents, spices, or citrus.
• Cosmetics that have an irritating or drying effect should not be used in simultaneously with Epiduo Forte.
• Limit your exposure to sunlight
• When outdoors, wear protective clothing and apply a non-comedogenic, broad-spectrum sunscreen with an SPF of 50 or higher.
Does it have any side effects?

Skin irritation occurs after applying Epiduo Forte Gel, typically mild to moderate and may include local symptoms such as redness, dryness, scaling, stinging, and burning. These symptoms usually peak within the first two weeks and then resolve on their own.

Epiduo Forte Gel may sometimes cause adverse effects at the application site. Inform your doctor if you experience any of the following symptoms, particularly if they become severe, or if you notice any side effects that are not included in this list.

• Itching
• Rash
• Atopic dermatitis
• Eczema
• Dry skin
• Swelling face
• Throat tightness
• Blisters (vesicles)
• Skin discoloration
• Urticaria (hives)
• Anaphylactic reaction

If the symptoms do not go away or are life-threatening, immediately stop taking the medication and inform your doctor or call an ambulance for professional medical assistance.

Is it safe to take it with another drug?

Maintain a list of all products you use and share it with your doctor or pharmacist. Do not begin, discontinue, or alter the dosage of any medications without your doctor’s approval.

Some products that may interact with this medication include other drugs that can increase your sensitivity to sunlight.

• Tetracyclines, Thiazide diuretics: Hydrochlorothiazide
• Sulfa medications: Sulfamethoxazole
• Quinolone antibiotics: Ciprofloxacin
• Other acne treatments: Tretinoin, Dapsone

Avoid using other skin products that are harsh, irritating, or drying on the treated area. This includes hair perming solutions, products containing alcohol, lime, or menthol such as astringents, toners, and shaving lotions, medicated or abrasive soaps and cleansers, as well as soaps and cosmetics with strong drying effects like alpha hydroxy acids and glycolic acid, and products containing sulfur, resorcinol, or salicylic acid.

If you have recently used products containing sulfur, resorcinol, or salicylic acid, use this product with caution. Wait until the effects of products on your skin have diminished before applying this product.

How should I store it?

Store below 25°C and do not refrigerate. The shelf life after opening is 3 months.

What action should I take in case of overdose?

Epiduo Forte Gel is for external use only. If ingested, seek immediate medical attention.

Is it safe for pregnant or breastfeeding women?

Epiduo Forte Gel should not be used by pregnant or planning to become pregnant during treatment. If an unexpected pregnancy occurs, the treatment should be stopped immediately.

Epiduo Forte Gel should be used with caution by women who are breastfeeding. To prevent contact exposure to the infant, it should only be applied to areas away from the chest while breastfeeding.

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