NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Gleostine prescribed?

Gleostine (Lomustine) is used to treat brain tumors in individuals who have previously undergone surgery or radiation. It is also used in combination with other cancer medications to treat Hodgkin's disease when other treatments have not been effective.

What does it do?

Gleostine works by inhibiting the growth of cancer cells, leading to their eventual destruction.

How should I take it?

Gleostine is taken as a single dose every 6 weeks. Be sure to follow your doctor's dosing instructions precisely. Since an overdose of lomustine can be fatal, you will only be provided with enough Gleostine for one dose every 6 weeks. To ensure you receive the correct dose, you may need to take two or more capsules of different types and colors.

When handling a Gleostine capsule, wear disposable rubber gloves and dispose of them after use.

What if I missed a dose?

It is crucial not to skip your dose. If you are unable to take it or miss it, contact your doctor or healthcare provider for instructions.

What are the special precautions before taking Gleostine?

Inform your doctor about all the medications you are taking, your current and previous medical history.

• Bone marrow suppression
• Liver disease
• Kidney disease
• Lung disease or breathing problems

Gleostine can weaken your immune system, increasing the risk of serious and potentially fatal infections that may occur up to 6 weeks after treatment. You will need regular medical tests during this time.

Do not open the Gleostine capsule or use a broken pill. The medication from a broken pill can be harmful if it comes into contact with your skin. If this occurs, clean the affected area with soap and water. Consult your doctor or pharmacist for guidance on how to safely handle and dispose of a broken capsule.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Side effects that typically do not require medical attention:

• Hair loss
• Nausea
• Vomiting

Serious side effects may include:
• Cough
• Confusion
• Mouth sores
• Breathing problems
• Changes in vision
• Low blood counts – this medication may reduce the number of red blood cells, white blood cells, and platelets, increasing the risk of infections and bleeding
• Signs of infection – fever or difficulty urinating
• Symptoms of low platelets or bleeding – bruising, blood in the urine
• Signs of kidney injury – difficulty urinating or changes in urine output
• Signs of liver injury – dark yellow or brown urine, light-colored stools, yellowing of the skin or eyes

This side effects that should be reported to your doctor or healthcare professional immediately.

Is it safe to take it with another drug?

Some drug interactions may cause serious or life-threatening reactions when administered together. Immediately inform your doctor if you are taking Gleostine with any of the following medications:

• Cimetidine
• Vaccines

This list may not include all possible interactions. Be sure to provide your healthcare provider with a complete list of all medicines you are taking.

How should I store it?

Store Gleostine at room temperature, away from heat and moisture. Keep the bottle tightly closed until you're ready to use it.

What action should I take in case of overdose?

If you suspect an overdose of Lomustine, seek emergency medical help immediately. An overdose can be life-threatening.

Is it safe for pregnant or breastfeeding women?

Before using Lomustine, inform your doctor if you are pregnant or planning to become pregnant, as it can harm an unborn baby. Women should use reliable birth control during treatment and for at least 2 weeks after the last dose. Men should use reliable birth control during treatment and for 4 months after the last dose. If pregnancy occurs, consult your doctor about the risks and benefits of continuing treatment.

Since Lomustine can be absorbed through the skin and lungs, women who are pregnant or may become pregnant should avoid handling the medication or inhaling dust from the capsules.

It is unclear if Lomustine passes into breast milk. Due to potential risks to the infant, breastfeeding is not recommended during treatment and for 2 weeks after the last dose. Always consult your doctor before breastfeeding.

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