Why is Imuran prescribed?

Imuran (Azathioprine) is a drug that suppresses the immune system and acts as an antimetabolite. It is used to prevent the rejection of transplanted kidneys, liver or heart and to alleviate symptoms of rheumatoid arthritis.

What does it do?

Imuran (Azathioprine) is used to prevent organ rejection in kidney transplant recipients, usually in combination with other medications to support normal kidney function. It is also used in the treatment of rheumatoid arthritis, a condition where the immune system mistakenly attacks healthy joints. Azathioprine is classified as an immunosuppressant and works by reducing the activity of the immune system. This can help the body accept a transplanted kidney as its own or prevent further joint damage from rheumatoid arthritis.

It's important to discuss with your doctor the advantages and potential drawbacks of azathioprine, especially when considering its use in children and young adults.

How should I take it?

Take Imuran (Azathioprine) as instructed by your doctor, usually once or twice daily with food to reduce stomach discomfort. The dose depends on your medical condition, weight, and how well you respond to treatment. Do not exceed the prescribed dose or use it more frequently or for longer than recommended. Doing so won't speed up your recovery and may increase your risk of serious side effects. Use this medication continuously to get the most benefit.

To help remember, take it at the same time(s) daily. For arthritis treatment, it may take up to 2 months to see improvement in symptoms.

Tell your doctor if your condition doesn't improve after 3 months of treatment.

What if I missed a dose?

If you forget to take a dose, take it as soon as you remember. Do not take a double dose to make up for a missed dose.

What are the special precautions before using Imuran?

Before starting taking Azathioprine, notify your doctor or pharmacist if you are allergic to it and 6-mercaptopurine (Puri-Nethol), or have any other allergies.

Always inform your doctor or pharmacist of your medical history, particularly if you have kidney disease, liver disease, cancer, or specific enzyme disorders like thiopurine methyltransferase (TPMT) deficiency or NUDT15 deficiency. Azathioprine may increase your risk of developing skin cancer. Reduce sun exposure and use sunscreen as well as protective clothing when outdoors.

Azathioprine can raise your susceptibility to infections or worsen existing infections. Avoid contact with people who have contagious illnesses that can spread easily, like chickenpox, COVID-19, measles, or the flu. Notify your doctor if you have been exposed to an infection or need more information.

Before undergoing any dental surgery, tell your dentist and doctor that you are using Azathioprine before receiving any vaccinations.

Does it have any side effects?

While taking this medication, certain side effects may occur that require immediate medical attention.

Common side effects may include:
• Any infections (Bacterial, Fungal, Viral)
• Blood in urine or stools
• Nausea
• Unusual tiredness or weakness
• Vomiting

Serious side effects may include:
• Allergic reactions
• Abdominal pain
• Blistering or peeling of the skin
• Muscle pain
• Jaundice
• Hair loss (kidney transplant)

Your healthcare provider can provide guidance on managing or preventing these effects. If you have concerns about side effects or notice any other unusual reactions, consult your doctor promptly.

Is it safe to use it with another drug?

Drug interactions can alter how your medications function or heighten your risk of severe side effects. Do not begin, cease, or modify the dose of any medications without consulting your doctor.

Certain products that may interact with this medication include:

• Allopurinol (Gout)
• Captopril
• Cimetidine
• Co-trimoxazole
• Cyclosporine
• Furosemide
• Methotrexate
• Penicillamine (Rheumatoid arthritis)
• Sulfasalazine
• Sulfamethoxazole
• Warfarin

Azathioprine closely resembles a mercaptopurine. Refrain from using medications containing mercaptopurine while taking azathioprine.

Ask your doctor or pharmacist for other possible interactions not listed in this section.

How should I store it?

Store at room temperature and protect from light.

What action should I take in case of overdose?

If someone has overdosed and is experiencing severe symptoms. Seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

Inform your doctor if you are pregnant or intend to conceive. It's essential not to become pregnant while taking Azathioprine because it could harm an unborn baby. Discuss reliable methods of birth control with your doctor while using this medication. If you become pregnant, promptly consult your doctor regarding the risks and benefits of continuing Azathioprine therapy.

Azathioprine passes into breast milk and may have adverse effects on a nursing infant. Seek advice from your doctor before breastfeeding while using this medication.

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