NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Jakafi prescribed?

Jakafi (Ruxolitinib) is used to treat chronic idiopathic myelofibrosis and polycythemia vera.

What does it do?

Jakafi is an anti-cancer medication that works by inhibiting the abnormal protein responsible for signaling cancer cells to grow. This helps to prevent or slow the spread of cancer cells.

How should I take it?

Take Jakafi exactly as prescribed by your doctor based on your condition. The starting dose of Jakafi in PV is 10mg twice a day and for Myelofibrosis will be based on your platelet count. Jakafi can be taken with or without food, but it’s best to take it at the same time each day.

Complete blood count, including a white blood cell count differential, before starting this medication and monitoring is needed after 2 weeks.

What if I missed a dose?

If you miss Jakafi, take it as soon as possible. If it's nearly time for your next dose, just take that one. Do not double dose.

What are the special precautions before taking Jakafi?

Inform your doctor about all the medications you are taking, your current and previous medical history.

Before taking Jakafi, inform your healthcare provider if you:

• Have an infection
• Have any other medical conditions
• Have or have had liver or kidney problems
• Are on dialysis (take Jakavi after dialysis)
• Are pregnant or planning to become pregnant (the effects on an unborn baby are unknown)
• Are breastfeeding or planning to breastfeed (it is unclear if Jakafi passes into breast milk; you should not breastfeed while taking Jakafi)

Specifically mention if you're taking medications for:

• HIV/AIDS
• Fungal infections
• Bacterial infections

If you're unsure whether a medicine falls into these categories, ask your healthcare provider or pharmacist. Keep an updated list of all your medications to share with your provider and pharmacist when starting a new medication.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Contact your doctor immediately if you experience any of the following side effects:

• Allergic reactions (skin rash, itching)
• Anemia (lightheaded, weak, or unusually tired)
• Blood clot (chest pain, swelling, or warmth)
• Unusual bruising or bleeding
• Heart attack (chest, neck, trouble breathing, unusual fatigue)
• Infection (fever, chills, or difficult urination)
• Stroke (speech difficulties, trouble walking, dizziness, loss of coordination)

Side effects that are typically not serious but should be reported if persistent or bothersome include:

• Diarrhea
• Headache
• Muscle cramps
• Swelling in the arms or legs

This list may not include all possible side effects. Contact your doctor for advice on any side effects you experience.

Is it safe to take it with another drug?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

• Conivaptan
• Enzalutamide
• Grapefruit juice
• Idelalisib
• Apalutamide
• Certain antifungal drugs (e.g., Fluconazole)
• Certain antibiotics (e.g., Clarithromycin, Erythromycin)
• Seizure medications (e.g., Carbamazepine)
• Lumacaftor; Ivacaftor
• Mifepristone
• Mitotane
• Nefazodone
• Ribociclib
• Rifampin
• HIV or AIDS antiviral medicines
• St. John’s wort

This is not a complete list of interactions. Make sure to inform your doctor about all the medications you are taking as well as your smoking, alcohol as some of these may interact with your medication.

How should I store it?

Store Jakafi in a tightly closed container at room temperature, away from moisture, heat, and direct sunlight. Do not freeze.

What action should I take in case of overdose?

If you suspect an overdose of Jakavi, contact your doctor or go to the emergency room immediately.

Is it safe for pregnant or breastfeeding women?

Jakavi should not be used by women who are pregnant or breastfeeding. Talk to your doctor before starting this medication to carefully consider the potential risks and benefits.

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