NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Mestinon tablets contain pyridostigmine, an active ingredient classified as an anticholinesterase. This type of medication enhances communication between nerves and muscles useful in the treatment of myasthenia gravis.

What does it do?

This medication functions by inhibiting the breakdown of a natural substance in your body called acetylcholine. Acetylcholine is essential for normal muscle function and lessen muscle weakness.

How should I take it?

Take this medication orally as prescribed by your doctor. Do not crush or chew the tablets. The dosage depends on your medical condition and how you respond to the treatment.

What if I missed a dose?

If you forget a dose, talk to your doctor. Mestinon treatment is personalized and will also consider if you are taking immediate-release or extended-release tablet forms. This makes missing a dose more complicated.

What are the special precautions before taking Mestinon?

Inform your doctor about all the medications you are taking, your current and previous medical history.

Do not use Mestinon if:

• Your digestive tract is twisted or obstructed.
• You are unable to urinate due to an obstruction.
• You are allergic to pyridostigmine, bromine, or any of the other ingredients in this medication.

Consult your doctor or pharmacist before taking Mestinon tablets if you have any of the following conditions:

• Chronic obstructive pulmonary disease (COPD) or bronchial asthma
• Bradycardia: slow heart rate.
• Recent blockage of a blood vessel supplying the heart.
• Epilepsy.
• Low blood pressure.
• Parkinson’s disease
• Stomach ulcer.
• Vagotonia: disruption of the vagus nerve that leads to symptoms such as constipation and muscle spasms..
• Hyperthyroidism.
• Renal impairment.
• Kidney disease.
• Irregular heartbeat, particularly if you are elderly.
Does it have any side effects?

All medications have the potential to cause allergic reactions, although severe reactions are quite rare. Notify your doctor immediately if you experience sudden wheezing, difficulty breathing, swelling of the body parts, rash or itching, particularly if it affects your entire body.

• Syncope: temporary loss of consciousness caused by a drop in blood pressure
• Miosis: increased tearing (watering of the eyes) and accommodation issues (such as blurred vision)
• Arrhythmia: issue with the heart's rate or rhythm
• Flushing
• Increased bronchial secretions along with bronchial constriction.
• Hives
• Muscle twitching
• Tremors
This document does not list all possible side effects, and other effects may also occur. Please consult your doctor for more information about side effects.
Is it safe to take it with another drug?
Taking these tablets alongside certain other medications may alter the effects of either this medication or the other drugs. Inform your doctor or pharmacist if you are currently taking:
• Anticholinergic medications, such as atropine or hyoscine, which are commonly used to treat vomiting or diarrhea.
• Muscle relaxants, including Pancuronium or Suxamethonium.
• Aminoglycoside antibiotics, local and certain general anesthetics, antiarrhythmic agents, and other medications that affect neuromuscular transmission may interact with pyridostigmine bromide.
• Immunosuppressants medication, the need for pyridostigmine bromide may be reduced when additional treatments, such as steroids or immunosuppressant drugs, are administered. However, high doses of corticosteroids may lead to a decrease in the peak plasma concentration and the area under the curve (AUC) of pyridostigmine.
Ask your doctor or pharmacist for other possible interactions not listed within this section.
How should I store it?

Store below 25 °C in the original packaging and ensure the bottle is tightly closed.

What action should I take in case of overdose?

Contact your doctor immediately if you experience signs of an overdose, which may include muscle or abdominal cramps, diarrhea, nausea, vomiting, excessive saliva, constricted pupils, weakness, muscle twitching, and a slow heart rate.

Is it safe for pregnant or breastfeeding women?

This medication should be used during pregnancy only when absolutely necessary. Discuss the potential risks and benefits with your doctor. Although this medication does pass into breast milk, it is unlikely to harm a nursing infant. Consult your doctor before breastfeeding.

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