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Why is Migranal Nasal Spray prescribed?

Migranal Nasal Spray (Dihydroergotamine) is primarily prescribed to adults for the acute treatment of migraine headaches, whether they come with or without an aura. It's designed to provide quick relief from migraine attacks once they've started.

What does it do?

Dihydroergotamine, the active ingredient, works by narrowing the blood vessels around the brain, which helps alleviate the throbbing pain associated with migraines.

The nasal spray allows the medication to be absorbed quickly through the nasal mucosa, offering faster relief compared to some oral medications.

How should I take it?

It's important to always read the label and follow your healthcare provider's instructions precisely. Typically, the recommended dose is one spray in each nostril, which may be repeated after 15 minutes if needed, not exceeding a total of four sprays (2 mg) during a single migraine attack.

Do not use more than the prescribed amount. It's important to limit usage to no more than two treatments within a 24-hour period and no more than three migraine attacks per week to avoid medication overuse headaches.

Additional usage information:

• Migranal Nasal Spray should only be used as soon as your headache begins, but it can also be used at any time during a single migraine episode.
• Before using it for the first time, prime the nasal spray device with 4 sprays into the air, away from your face.
What if I missed a dose?
If you intended to use Migranal Nasal Spray at the start of a migraine but forgot, you can administer the dose as soon as you remember. Keep in mind that Migranal is most effective when used at the first signs of a migraine. Avoid using extra doses to make up for the missed administration and stick to the prescribed dosing instructions to prevent potential side effects.
What are the special precautions before taking Migranal Nasal Spray?

Before using Migranal Nasal Spray (Dihydroergotamine), it's important to be aware of certain precautions to ensure the medication is safe and effective for you. Here are the special precautions to keep in mind:

• Migranal Nasap Spray is intended for treating active migraines and is not used to prevent migraines from occurring.
• Ensure your doctor is aware of any other medications you're taking, especially antifungals, HIV protease inhibitors, and macrolide antibiotics, as these can interact with Dihydroergotamine.
• Avoid use if you have a history of heart disease, kidney or liver disease, peripheral vascular disease, or hypertension, or if you are pregnant or nursing, without first consulting your healthcare provider.
• Avoid use if you have a history of stroke or mini-strokes, as Migranal can cause blood vessels in the brain to narrow.
Does it have any side effects?
It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.
Common side effects may include:
• Changes in sense of taste
• Nasal congestion or irritation
• Nausea or dizziness
• Fatigue
• Sore throat
• Vomiting
Serious side effects may include:
• Chest pain or tightness
• Fever
• Irregular heartbeat
• Severe abdominal pain
• Shortness of breath
• Numbness or tingling in the extremities
• Signs of an allergic reaction (rash, itching, swelling)

This list doesn't include all possible side effects, and others may occur. Always seek medical advice from your healthcare provider regarding any side effects.

Is it safe to take it with another drug?

It’s crucial to inform your healthcare provider about all the medications you are currently taking, as many drugs can interact with dihydroergotamine. Particular attention should be given to:

• Antidepressants
• Heart or blood pressure medications
• Nicotine gum or patches
• Medications for asthma

This list is not complete, as numerous other drugs may interact with dihydroergotamine. This includes prescription medications.:

How should I store it?

Keep the Migranal nasal spray at room temperature, between 68°F to 77°F (20°C to 25°C), in its original, tightly sealed container or box. Store it in a cool, dry place away from direct heat or sunlight. Ensure its somewhere you can grab quickly when you feel a migraine coming on, and keep it out of reach of children and pets.

What action should I take in case of overdose?
In case of an overdose of Migranal nasal spray (Dihydroergotamine), promptly seek medical attention initial signs and symptoms are nausea and vomiting.
Is it safe for pregnant or breastfeeding women?

Migranal nasal spray may induce uterine contractions, which could lead to miscarriage. If you are pregnant or planning to become pregnant, consult with your doctor about alternative treatments. Additionally, it is not recommended for use while breastfeeding, as the medication can be passed into breast milk. You may need to decide between discontinuing the drug or stopping breastfeeding.

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