Why is Mysoline prescribed?

Primidone (Mysoline) is prescribed alone or in combination with other medications for the treatment of different types of seizures such as grand mal, psychomotor, and focal epileptic seizures. It is also used to treat essential tremor (a disorder of the nervous system causing uncontrollable shaking).

What does it do?

Seizures are caused by a disruption in the communication pathways in the brain that may cause behavioral changes, loss of consciousness, or uncontrollable movement of the arms and legs. Primidone belongs to a drug class called anticonvulsants and it works by lessening the electrical activity and excitability in the brain that is not normal.

How should I take it?

Mysoline and its generic equivalents are currently available as 250mg tablets. Each tablet should be taken as a whole (do not split) by mouth with or without food.

The dosage strength depends on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only use this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before taking Mysoline?

Before taking Primidone, tell your doctor or pharmacist if you have any allergies to food or to the drug itself as it may contain several inactive ingredients, which can cause allergic reactions or problems.

Inform your doctor about your past and current medical history especially if you have or have had porphyria (a condition that affects the skin and nervous system), depression, mood disorders, and suicidal thoughts or actions.

Taking Primidone may cause changes in your mental health and you may develop suicidal thoughts. Consult your doctor if you experience symptoms such as anxiety, depression, or panic attacks and make sure your family or caregiver is aware of these symptoms.

For the drug label information of Mysoline, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Appetite loss
• Balance problems
• Dizziness
• Drowsiness
• Nausea
• Rashes
• Vision problems
• Vomiting

Serious side effects include:
• Behavioral changes
• Bruising or bleeding easily
• Changes in thoughts
• Chills
• Fever
• Loss of balance or coordination
• Sore throat
• Tiredness

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Mysoline with any of the following medications:

• Alfentanil
• Bedaquiline
• Buprenorphine
• Buspirone
• Butorphanol
• Calcort
• Capmatinib
• Cobicistat
• Cordarone
• Corlanor
• Crizotinib
• Darolutamide
• Darunavir
• Dasatinib
• Delavirdine
• Dynacirc CR
• Eliquis
• Encorafenib
• Etonogestrel
• Everolimus
• Flibanserin
• Guanfacine
• Haloperidol
• Hydrocodone
• Irinotecan
• Ixazomib
• Latuda
• Lefamulin
• Lorlatinib
• Meperidine
• Morphine
• Nalbuphine
• Nicardipine
• Norvasc
• Oxycodone
• Pentazocine
• Pradaxa
• Prograf
• Remifentanil
• Samsca
• Seroquel
• Zytiga

If you are using any prescription, non-prescription, and herbal medications, inform your doctor and pharmacist for proper information and ask for other possible interactions not listed within this section.

How should I store it?

Store Mysoline at room temperature (25 °C) in a clean environment away from light and moisture, as well as children and pets. Do not refrigerate. Do not remove the desiccant in the original container. Throw away if unused or expired. Do not flush in the toilet. Consult the pharmacist for proper disposal.

What action should I take in case of overdose?

Call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

There are only limited studies and data regarding the safety of Primidone to determine drug-associated risks of major maternal defects, miscarriages, and fetal outcomes.

Data indicates the presence of Primidone in human milk. Consult your doctor first before breastfeeding.

The use of Primidone in pregnant and breastfeeding women should be avoided unless the potential benefits outweigh the risks.

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