Nardil (Phenelzine) is a monoamine oxidase inhibitor (MAOI) antidepressant commonly prescribed to address the symptoms of depression, including sadness, anxiety, fear, and health-related worries (hypochondria). It is typically recommended when other antidepressants have not been effective in managing these symptoms.

Nardil is a monoamine oxidase inhibitor (MAOI) that works by blocking a protein in the brain responsible for breaking down certain neurotransmitters, including norepinephrine, dopamine, and serotonin. By preventing the breakdown of these chemicals, phenelzine allows them to remain in the brain longer, which can enhance mood and overall emotional well-being.

Follow all instructions on your prescription label and read any medication guides or instruction sheets provided. Your doctor may adjust your dose from time to time, use the medication exactly as prescribed.

It may take several weeks to experience the full effects of Nardil. Your doctor will decide the duration of your treatment. Do not stop taking Nardil abruptly, as this could lead to uncomfortable withdrawal symptoms. Consult your doctor for assistance on how to safely discontinue the medication.

Take Nardil as soon as you remember, but if it's nearly time for your next dose, skip the missed dose. Do not double dose at once to catch up the missed dose.

There are numerous other medications, foods, and drinks that can lead to dangerously high blood pressure if taken with Nardil. Make sure to tell your doctor about all the medications you're currently taking, as well as any you begin or stop using. It's also important to avoid alcohol and be aware of which foods you should steer clear of.

• Tumor of the adrenal gland (pheochromocytoma)
• Severe kidney disease
• Congestive heart failure
• A history of liver issues or abnormal liver function test results.
Inform your doctor if you have a history of:
• Diabetes
• High blood pressure
• Heart disease
• Epilepsy or other seizure disorder
• Schizophrenia, or
• If you have used another antidepressant in the past 5 weeks, let your doctor know.

Some young people may experience suicidal thoughts when they first start taking an antidepressant. Be vigilant about any changes in your mood or symptoms and inform your doctor of any new or worsening issues.

Avoid drinking alcohol, as it may cause serious side effects.

Nardil may affect your ability to think clearly or react quickly. Use caution when driving or engaging in activities that require full alertness.

Does it have any side effects?
These side effects may improve as your body adjusts to the medication. However, if they persist or worsen, contact your healthcare provider right away.
Common side effects may include:
• Dizziness
• Drowsiness
• Sleep problems (difficulty in sleeping)
• Tremors
• Fatigue
• Constipation
• Overactive reflexes
• Gut problems
• Fluid retention, bloating
• Sexual dysfunction
• Weight gain
Serious side effects may include:
• Suicidal thoughts or self-harm
• Serotonin syndrome: sweating, muscle stiffness or spasms, fast heartbeat, and confusion
• Dangerously high blood pressure: changes in your heart rate, neck stiffness or soreness, fever, clammy skin, sensitivity to light, or severe headache.
If you experience any of the following, contact your healthcare provider right away.

Other side effects not mentioned may also occur in some individuals. If you notice any additional symptoms, consult your doctor.

Is it safe to take it with another drug?

A serious drug interaction may occur between Nardil and certain medications taken within 14 days before or after using this medicine. If you need to take any of these medications, your doctor may adjust your treatment plan, including:

• Epinephrine or norepinephrine
• ADHD medication
• Bupropion, Guanethidine, Meperidine, Tryptophan
• Diet pills
• Opioid medicine
• Cough and cold or allergy medicines
• Another MAO inhibitor such as furazolidone, linezolid, procarbazine, selegiline, methylene blue injection, and others
• Medications that affect serotonin levels in your body such as stimulant medicine, herbal products, mental illness medication for depression, mental illness, Parkinson's disease, prevention of nausea and vomiting.

Many other drugs can cause serious health issues if taken with Nardil, including prescription and over-the-counter medications, herbal supplements, and vitamins.

This medication guide does not list all possible interactions. Be sure to inform your doctor about all the medications you're currently taking, as well as any that you begin or discontinue.

How should I store it?

Store the medication at room temperature, away from light and moisture, and keep it in its original packaging. Do not store it in the bathroom. Keep all medications out of reach of children.

What action should I take in case of overdose?

If someone has overdosed and is experiencing severe symptoms, such as agitation or difficulty in breathing, contact your doctor immediately.

Is it safe for pregnant or breastfeeding women?

Nardil should only be used during pregnancy if prescribed by your doctor. It is not known whether this medication passes into breast milk, best to consult your doctor before breastfeeding.

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