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Why is Neoral prescribed?

Neoral (Cyclosporine) is prescribed to prevent organ rejection after kidney, liver, or heart transplants by suppressing the immune system. It also treats severe psoriasis, a chronic skin condition, and severe rheumatoid arthritis, an autoimmune disorder causing joint pain and damage.

What does it do?

Neoral (Cyclosporine) works by suppressing the immune system. It does this by inhibiting the activity of certain immune cells (T-cells) that can cause inflammation and damage to transplanted organs or tissues. Specifically, Neoral inhibits an enzyme called calcineurin, which is crucial for the activation of T-cells. By doing so, it helps prevent organ rejection in transplant patients and reduces inflammation in conditions like severe psoriasis and rheumatoid arthritis.

How should I take it?

To take Neoral (Cyclosporine) effectively, follow these guidelines:

• Take Neoral at the same time each day to maintain consistent levels in your body.
• Take Neoral with food or milk to reduce stomach upset.
• Swallow the capsules whole without crushing, chewing, or opening them.
• Avoid grapefruit and grapefruit juice, as they can increase the levels of Neoral in your blood and lead to side effects.
• Your doctor will determine the appropriate dose based on your condition and response to treatment. Do not change your dose without consulting your doctor.

It's important to follow your doctor's instructions closely and report any side effects or concerns you may have.

What if I missed a dose?

If you miss a dose of Neoral (Cyclosporine), take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and take your next dose at the regular scheduled time. Do not double up to make up for the missed dose.

What are the special precautions before taking Neoral?

Before taking Neoral (Cyclosporine), these are the important precautions to keep in mind:

• Tell your doctor if you are allergic to cyclosporine or any other ingredients in Neoral
• Discuss your medical history with your doctor, especially if you have conditions like cancer, kidney problems, or high blood pressure.
• Provide a list of all medications, supplements, and over-the-counter drugs you are taking, as Neoral can interact with many substances.
• Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
• Be aware that Neoral can increase your risk of infections. Wash your hands often and avoid contact with people who are sick.
• Neoral can make your skin more sensitive to sunlight, so use sunscreen and wear protective clothing when outdoors.

It's crucial to follow your doctor's instructions and attend all scheduled appointments to ensure safe and effective use of Neoral.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Acne
• Diarrhea and constipation
• Headache
• Nausea
• Stomach pain or upset
• Dizziness
• Cramps
• Skin rash, or pale red bumps on the skin
• Swollen/red/painful gums

Serious side effects may include:
• Severe headache
• Swelling of the face, lips, or tongue
• Irregular heartbeats or palpitations
• Blurred vision
• Difficulty breathing
• Loss of appetite
• Yellowing of the skin or eyes

This list does not cover all of the potential side effects, and others may occur. For additional information about side effects, please consult your healthcare provider.

Is it safe to take it with another drug?

Taking Neoral (Cyclosporine) with other drugs can be risky due to potential interactions. Neoral can interact with a variety of medications, including those used for treating infections, high blood pressure, heart conditions, and other immune system-related conditions1. Some common drugs that may interact with Neoral include:

• ACE inhibitors
• Etoposide
• Lithium
• Methotrexate
• Nefazodone
• Heart or blood pressure medications
• Medications used to treat ulcerative colitis
• Other immunosuppressants
• Pain or arthritis medications
• IV antibiotics
• Antiviral medications
• Cancer medications
• St. John's wort

It's crucial to inform your healthcare provider about all the medications, supplements, and over-the-counter drugs you are taking. They can help you manage potential interactions and adjust your treatment plan accordingly.

How should I store it?

Store Neoral at room temperature in its original packaging to protect it from light and moisture. Ideally, a temperature between 20°C and 25°C (68°F and 77°F) is recommended, and avoid exposing it to direct sunlight or any sources of strong light.

What action should I take in case of overdose?

In case of an overdose with Neoral (Cyclosporine) it's important to seek medical attention immediately. Contact emergency services or go to the nearest hospital right away.

Is it safe for pregnant or breastfeeding women?

Neoral (Cyclosporine) should be used during pregnancy only if the potential benefits outweigh the risks. It's important to discuss this with your healthcare provider to make an informed decision.

For breastfeeding, Neoral is excreted into breast milk, and while most infants studied did not have detectable blood levels, some did. Breastfeeding should be carefully considered, and infants should be monitored for any adverse effects. Always consult your healthcare provider for personalized advice and to discuss alternative options if you are pregnant or breastfeeding.

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