Why is Nitrostat prescribed?

Glyceryl trinitrate (Nitrostat) is prescribed for the treatment of angina (chest pain) in patients with coronary artery disease. It may also be administered before doing activities that trigger an angina attack, to prevent its occurrence.

What does it do?

Angina (chest pain) is commonly caused by coronary artery disease. It occurs when there is a decrease of blood flow to the heart and you may feel squeezing or tightness in your chest. Glyceryl trinitrate is classified as a vasodilator and it is converted into nitric oxide, which then activates an enzyme causing the widening of the blood vessels to reduce the workload of the heart.

How should I take it?

Nitrostat and its generic equivalents are currently available as 0.3mg sublingual tablets. Each tablet should only be put under the tongue and be allowed to dissolve. It should not be chewed or swallowed.

The dosage strength depends on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only use this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before taking Nitrostat?

Before taking Glyceryl trinitrate, tell your doctor or pharmacist if you have any allergies to food or to the drug itself as it may contain several inactive ingredients, which can cause allergic reactions or problems.

Inform your doctor about your past and current medical history especially if you have or have had a heart attack, anemia, brain tumors, head injuries, low blood pressure, heart failure, or any heart disease.

Glyceryl trinitrate may cause dizziness when getting up abruptly. When getting up from a lying or sitting position, do it slowly and sit for a few minutes before standing up completely.

Glyceryl trinitrate may cause headaches when taken. Continue taking the medication as necessary.

Limit alcohol intake to reduce occurrence of side effects associated with taking Glyceryl trinitrate.

For the drug label information of Nitrostat, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Dizziness
• Flushing
• Headaches
• Increased sweating
• Mild burning or tingling sensation in the mouth

Serious side effects include:
• Blurred vision
• Difficulty breathing
• Dry mouth
• Lightheadedness
• Nausea
• Slow heart rate
• Vomiting
• Weakness

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Nitrostat with any of the following medications:

• Altace
• Amisulpride
• Asendin
• Avanafil
• Buprenorphine
• Cariprazine
• Cialis
• Clorazepate
• Clozapine
• Dapsone
• Dostinex
• Dronabinol
• Dynacirc CR
• Ergotamine
• Ertugliflozin
• Fluphenazine
• Fosinopril
• Furazolidone
• Guanfacine
• Haloperidol
• Heparin
• Hydroxyzine
• Iloprost
• Imipramine
• Jardiance
• Latuda
• Levitra
• Linezolid
• Lofexidine
• Lotensin
• Lumateperone
• Maprotiline
• Methotrimeprazine
• Mibefradil
• Nalbuphine
• Nesiritide
• Nortriptyline
• Orphenadrine
• Pentazocine
• Perindopril
• Plendil
• Promethazine
• Riociguat
• Selegiline
• Seroquel
• Sodium nitrite
• Univasc
• Viagra
• Zaleplon
• Zanaflex

If you are using any prescription, non-prescription, and herbal medications, inform your doctor and pharmacist for proper information and ask for other possible interactions not listed within this section.

How should I store it?

Store Nitrostat at room temperature (25°C) in a clean environment away from light and moisture, as well as children and pets. Do not refrigerate. Do not remove the desiccant in the original container. Throw away if unused or expired. Do not flush in the toilet. Consult the pharmacist for proper disposal.

What action should I take in case of overdose?

Call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

There are only limited studies and data regarding the safety of Nitroglycerin to determine drug-associated risks of major maternal defects, miscarriages, and fetal outcomes.

Limited data have been established indicating the presence of Nitroglycerin in human milk. Consult your doctor first before breastfeeding.

The use of Nitroglycerin in pregnant and breastfeeding women should be carefully evaluated to determine if its potential benefits outweigh the risks.

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