Odefsey is a three-drug combination (Emtricitabine/Rilpivirine/Tenofovir alafenamide) prescribed to treat Human Immunodeficiency Virus-1 (HIV-1) infection in adults and children who weigh at least 55 pounds (25 kg). The specific criteria are as follows:

• Have not previously taken anti-HIV-1 medications.
• Have a viral load (amount of HIV-1 in the blood) that is no more than 100,000 copies/mL.
• Are switching from other anti-HIV-1 medicines, provided they meet certain medical requirements.

Why is Odefsey prescribed?

Odefsey works by combining three active ingredients (emtricitabine, rilpivirine, and tenofovir alafenamide) which target HIV-1 in different ways to stop the virus from spreading in the body. With the 3 active ingredients combined, this medicine suppresses the amount of HIV-1 in the body (viral load), helping to maintain the health of the immune system and reduce the risk of complications.

How should I take it?

Odefsey is typically taken as one tablet (200 mg/25 mg/25 mg oral tablets) once daily with a meal, at the same time every day. Taking it with food ensures proper absorption of the medication into your body.

What if I missed a dose?

Missing doses of Odefsey may reduce its effectiveness over time, making it crucial to take every dose as prescribed without skipping. If you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

What are the special precautions before taking Odefsey?

Inform your doctor about all the medications you are taking, your current and previous medical history.

• Odefsey is not recommended for individuals with severe kidney impairment (creatinine clearance below 30 mL/min).
• Do not share Odefsey with others, even if they have the same condition, as it could potentially be harmful to them.
• Avoid taking Odefsey with medications that can reduce its effectiveness, such as certain anticonvulsants or proton pump inhibitors.
• Discuss with your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as the safety of Odefsey in these situations depends on individual circumstances.
• If you have both HIV and Hepatitis B virus, stopping Odefsey can lead to severe exacerbations, or worsening of hepatitis B. Make sure to attend all scheduled appointments for blood tests, as these allow your healthcare provider to monitor the health of your liver.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Headache
• Trouble sleeping
• Fatigue
• Depression
• Lack of appetite

Serious side effects may include:
• Difficulty breathing
• Symptoms of kidney problems such as reduced urination or swelling in the legs and feet
• Signs of liver damage such as yellowing of the skin or eyes, or dark urine
• Severe depression
• Nausea
• Swelling of the face, lips, or throat

This is not a complete list of all possible side effects, and others may occur. For more information about side effects, please consult your healthcare provider.

Is it safe to take it with another drug?

Odefsey can interact with other medications, but it’s important to be cautious, as some interactions may reduce its effectiveness, increase side effects, or cause other complications.

Odefsey should not be taken with certain drugs, such as rifampin or carbamazepine, as they can significantly reduce its effectiveness.
• Some medications, like antacids or proton pump inhibitors, may interfere with the absorption of Odefsey.
• Should not be used together with other antiretroviral drugs during treatment
• Some minor drug interactions are less likely to cause significant issues but should still be discussed with your healthcare provider.

How should I store it?

Odefsey should be stored in its original container with the cap tightly closed. Keep it in a cool, dry place where the temperature stays below 30°C (86°F). Keep it away from direct sunlight and out of reach of children and pets.

What action should I take in case of overdose?

If you suspect an overdose of Odefsey, it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital. Overdoes symptoms may include nausea, vomiting, dizziness, or unusual fatigue.

Is it safe for pregnant or breastfeeding women?

Odefsey should only be used during pregnancy if the potential benefits outweigh the risks. Some studies suggest that its components, such as tenofovir alafenamide, do not significantly increase the risk of congenital anomalies. A pregnancy registry is available for individuals taking Odefsey during pregnancy. Its purpose is to gather information about the health of both the parent and the baby. It is best to consult your doctor before using the medication when you get pregnant.

While for breastfeeding, it is generally not recommended for women with HIV to prevent the transmission of the virus to the baby.

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