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Why is Opzelura Cream prescribed?

Opzelura (Ruxolitinib) is commonly used to treat atopic dermatitis (eczema), which causes dry, itchy, and inflamed skin, as well as vitiligo, a condition where patches of skin lose their color.

What does it do?

Opzelura works by blocking certain pathways in an overactive immune system. For those with atopic dermatitis, it helps reduce skin inflammation, rashes, and redness. In people with vitiligo, Opzelura prevents the immune system from attacking skin pigment, which may help restore skin color.

How should I take it?

Opzelura is intended for external use on the skin only. Apply a thin layer twice daily and avoid using it in your mouth, eyes, or vaginal area.

What if I missed a dose?

If you forget to apply a dose of Opzelura, use it as soon as you remember. However, if it’s close to the time for your next scheduled dose, skip the missed dose and continue with your normal dosing routine.

What are the special precautions before taking Opzelura Cream?

Make sure to discuss the following with your doctor before using Opzelura. Opzelura may increase your risk of certain infections. Inform your doctor if you:

• Have a history of recurring infections
• Are being treated for or suspect an infection
• Have been exposed to someone with tuberculosis
• Live in areas with higher risk of specific fungal infections (e.g., Ohio or Mississippi River valleys, Southwest)

Tell your doctor if you have:

• Hepatitis B or C
• Any type of cancer
• Shingles (herpes zoster)
• Diabetes, HIV, or lung disease
• A weakened immune system
• Blood clots in legs or lungs
• Are a current or former smoker
• High cholesterol or triglycerides
• Heart problems or heart attack history

For atopic dermatitis (eczema): Stop using Opzelura once your rash and itching have cleared. Contact your doctor if symptoms persist after eight weeks.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Opzelura may cause serious side effects, including:

Serious side effects may include:
• Serious infections: Because Opzelura contains Ruxolitinib, a JAK inhibitor that affects the immune system, it can increase the risk of serious infections like tuberculosis and other bacterial, fungal, or viral infections. People with active infections should not use Opzelura, and your doctor will monitor you closely for signs of infection during treatment.
• Increased risk of death: People over 50 with heart disease risk factors taking JAK inhibitors by mouth have shown a higher risk of death from any cause.
• Cancer and immune problems: Opzelura may raise the risk of certain cancers, including lymphoma, lung cancer, and skin cancer, especially in current or past smokers. Your doctor will monitor your skin and advise you to limit sun exposure and use sunscreen.
• Heart problems: Increased risk of major cardiovascular events like heart attack or stroke has been observed in people over 50 with heart risk factors, especially smokers, taking oral JAK inhibitors.
• Blood clots: Opzelura can increase the risk of blood clots in the legs or lungs, which can be life-threatening, particularly in older adults with heart risk factors.
• Low blood cell counts: The medication may lower platelet, red, and white blood cell counts. Your doctor will monitor your blood regularly and may stop treatment if necessary.
• Cholesterol increases: Taking Ruxolitinib orally has been linked to increased cholesterol levels. Inform your doctor if you have high cholesterol or triglycerides.

Common side effects may include:
• Application site reactions such as itching, redness, or burning
• Acne
• Headache
• Cold symptoms like runny or stuffy nose
• Upper respiratory infections

Always discuss any concerns or symptoms with your doctor during treatment with Opzelura.

Is it safe to take it with another drug?

Certain medicines like Inhibitors of CYP3A4 may impact how Opzelura is processed in your body, potentially changing its effectiveness or side effects. It’s important to disclose all current and recent medications to your doctor.

This may not be a complete list of possible interactions, so always consult your doctor for advice.

How should I store it?

Store Opzelura (Ruxolitinib) at room temperature only. Avoid refrigerating or freezing it, as this may damage the medication.

What action should I take in case of overdose?

If too much Opzelura is used or swallowed, get emergency help right away as it can cause trouble breathing.

Is it safe for pregnant or breastfeeding women?

The effects of Opzelura on pregnancy and unborn babies are unknown. If you are pregnant, planning to become pregnant, or become pregnant while using Opzelura, inform your doctor. They will advise whether you should continue treatment.

It is also unknown if Opzelura passes into breast milk. You should not breastfeed while using Opzelura and for about four weeks after stopping the medication. Always inform your doctor if you are breastfeeding or planning to breastfeed.

Why is Opzelura Cream prescribed?

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