NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Pancreaze prescribed?

Pancreaze (Amylase/Lipase/Protease) is prescribed to treat exocrine pancreatic insufficiency (EPI), a condition where the pancreas does not produce enough enzymes to properly digest food. This insufficiency can result from conditions such as cystic fibrosis, chronic pancreatitis, pancreatic tumors, or after surgical removal of the pancreas.

What does it do?

Pancreaze works by substituting the digestive enzymes that your pancreas would normally produce. It contains lipases, proteases, and amylases, which are enzymes that help break down fats, proteins, and carbohydrates in the small intestine. These enzymes are delivered in enteric-coated microtablets, which protect them from being destroyed by stomach acid. Once they reach the small intestine, the enzymes are released and start working to digest food, aiding in nutrient absorption.

How should I take it?

Make sure to follow your healthcare provider's instructions for dosage, which depend on factors like age, weight, and dietary fat content. Take Pancreaze exactly as prescribed by your doctor, without exceeding the total daily dose.

Always take it with meals or snacks and plenty of fluids, and do not crush, chew, or hold the capsules in your mouth to avoid irritation or altered effectiveness.

For infants, administer Pancreaze right before feedings, but do not mix it directly with formula or breast milk. You may sprinkle the capsule contents on soft, acidic food like applesauce and give it immediately, ensuring all the medicine is swallowed.

For children and adults, swallow capsules whole with liquid, or sprinkle the contents on acidic food if swallowing is difficult. Consume the mixture immediately, drinking water or juice, and avoid storing mixed medicine.

What if I missed a dose?

If you miss a dose of Pancreaze, take it with the next meal or snack at your usual dose routine. However, if it’s almost time for your next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

What are the special precautions before taking Pancreaze?

Inform your doctor about all the medications you are taking, your current and previous medical history.

• Tell your doctor if you have any allergies, especially to pork products, as Pancreaze contains enzymes derived from pig pancreas.
• Share your medical history, particularly if you have conditions like fibrosing colonopathy (a rare bowel disorder), gout, kidney disease, or high levels of uric acid in your blood.
• Do not share this medication with others, even if they have the same condition, as it could potentially be harmful to them.
• If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor first to understand the potential risks.
• Follow your doctor's prescribed dosage carefully, as taking more than the recommended amount can increase the risk of side effects, such as fibrosing colonopathy.
• Tell your healthcare provider about all medicines you are taking. By doing so, it will help prevent potentially harmful drug interactions and ensure your safety.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Abdominal pain
• Diarrhea
• Vomiting
• Fatigue
• Headache

Serious side effects may include:
• Fibrosing colonopathy
• Difficulty breathing
• Swelling of the face, lips, tongue, or throat
• Elevated uric acid levels (Hyperuricemia)
• Severe stomach pain

This is not a complete list of all possible side effects, and others may occur. For more information about side effects, please consult your healthcare provider.

Is it safe to take it with another drug?

Pancreaze can interact with other medications, so it's important to take caution before combining it with other drugs.

Medications that may interact include iron supplements, antacids containing calcium carbonate, magnesium hydroxide, or aluminum hydroxide, and diabetes medications like acarbose and miglitol. Additionally, there is one known alcohol/food interaction and one disease interaction (hyperuricemia).

Always consult your healthcare provider before using Pancreaze alongside other medications to ensure it is safe and effective.

How should I store it?

Pancreaze should be stored in its original container at room temperature, ideally between 20°C and 25°C (68°F and 77°F). Keep it away from direct sunlight and out of reach of children and pets.

What action should I take in case of overdose?

If you suspect an overdose of Pancreaze, it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital. Symptoms of overdose may include severe abdominal pain, diarrhea, nausea, vomiting, or elevated uric acid levels, which can lead to gout or kidney issues.

Is it safe for pregnant or breastfeeding women?

It is not known if or how Pancreaze could affect pregnancy or harm an unborn baby. Therefore, Pancreaze should only be used during pregnancy if clearly needed and if the benefits outweigh the risks.

While for breastfeeding women, the safety of Pancreaze is uncertain and it is not known whether the drug passes into breast milk or affects the breastfed child. It's important to consult your doctor if you're pregnant or breastfeeding before using the medication to ensure safety.

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