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Why is Parlodel prescribed?

Parlodel, which contains Bromocriptine Mesylate, is prescribed for several medical conditions, such as hyperprolactinemia, Parkinson's disease, or type 2 diabetes. Parlodel (Bromocriptine) may also be used for other purposes and medications as determined by a healthcare provider.

What does it do?

Parlodel (Bromocriptine mesylate) acts as a dopamine receptor agonist, mimicking dopamine's actions in the brain. It suppresses prolactin secretion for hyperprolactinemia, lowers growth hormone levels for acromegaly, improves motor control in Parkinson's disease by addressing dopamine deficiency, and aids in regulating blood sugar for type 2 diabetes by enhancing insulin sensitivity.

How should I take it?

Parlodel should be taken with food to reduce stomach upset, and its dose varies based on the condition being treated as prescribed by your doctor. Here is some key dosage information to consider:

• For Hyperprolactinemia, the initial dose is 1.25–2.5 mg orally once daily, with gradual increases every few days as needed.
• For Acromegaly, the treatment starts with 1.25–2.5 mg at bedtime for three days, followed by gradual dose escalation.
• For Parkinson's disease, begin with 1.25 mg twice daily, adjusting the dose every few weeks.
• For Type 2 Diabetes, take 0.8 mg once daily within two hours of waking.

What if I missed a dose?

If you miss a dose of Parlodel, take it as soon as you remember. Do not take a double dose to make up for the missed one.

What are the special precautions before taking Parlodel?

Inform your doctor about all the medications you are taking, your current and previous medical history.

• Do not take Parlodel if you are allergic to Bromocriptine or any of the other ingredients in the medication.
• Share your medical history, especially if you have high blood pressure, heart disease, liver or kidney problems, or mental health conditions.
• This medication is not recommended for individuals who have recently given birth.
• Do not share this medication with others, even if they have the same condition, as it could potentially be harmful to them.
• Discuss with your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as Parlodel may not be suitable in certain situations.
• Avoid driving or operating heavy machinery until you know how Parlodel affects you, as it may cause dizziness or drowsiness.
• Limit alcohol intake, as it may increase the risk of side effects like dizziness.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Nausea and vomiting
• Dizziness
• Headache
• Fatigue
• Dry mouth

Serious side effects may include:
• Chest pain or difficulty breathing
• Uncontrolled muscle movements
• Bloody stools or vomiting blood
• Swelling of the face, lips, mouth, tongue, or throat
• Vision problems

This is not a complete list of all possible side effects, and others may occur. For more information about side effects, please consult your healthcare provider.

Is it safe to take it with another drug?

Parlodel may interact with certain medications such as antidepressants, antipsychotics, antihypertensive drugs, ergot alkaloids, and antibiotics like erythromycin, potentially affecting its effectiveness or increasing side effects, so it's important to take caution before combining it with other drugs.

Additionally, make sure to inform your healthcare provider if you are using any of the following before taking Parlodel:

• Dopamine agonists such as pramipexole, ropinirole, rotigotine, or apomorphine
• Medications for mental health conditions
• Diabetes medications
• Salicylates such as diflunisal, or salsalate for osteoarthritis/rheumatoid arthritis
• Probenecid, commonly used for gout
• Sulfamethoxazole/trimethoprim for bacterial infections
• Zonisamide for seizures

This is not a complete list of medicines that can interact with Parlodel.

How should I store it?

Parlodel should be stored in its original container at room temperature, ideally between 20°C and 25°C (68°F and 77°F). Keep it away from direct sunlight and out of reach of children and pets.

What action should I take in case of overdose?

If you suspect an overdose of Parlodel (Bromocriptine), it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital. Overdose symptoms may include nausea, vomiting, dizziness, confusion, hallucinations, or low blood pressure.

Is it safe for pregnant or breastfeeding women?

Parlodel is considered safe during pregnancy when the benefits outweigh the risks, though it is often discontinued upon confirmation of pregnancy unless medically necessary, such as for managing large pituitary tumors. Studies have not indicated an increased risk of birth defects, but its use requires a doctor's supervision.

However, Parlodel is typically not recommended for breastfeeding women due to its lactation-suppressing effects and potential risks, including maternal stroke, seizures, or cardiovascular issues. Always consult your healthcare provider to determine the best approach for your situation.

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