Why is Provera prescribed?

Provera, with the generic name Medroxyprogesterone acetate, is used to treat irregular menstruation or vaginal bleeding abnormalities. It is also prescribed to regularize menstruation in women who experienced amenorrhea (absence of menstruation) for at least 6 months who not pregnant or in menopause. It can also decrease the risk of developing cancer of the uterus by preventing the thickening of the lining of the uterus in patients taking estrogen.

What does it do?

Medroxyprogesterone, classified under progestins, prevents the growth of the uterine lining and causing the release of certain substances, to regulate menstruation and ovulation.

How should I use it?

Provera (Medroxyprogesterone) is currently available as 2.5mg, 5mg, and 10mg tablets, taken whole (not chewed or crushed), by mouth with or without food. It is used only to control your condition, not cure it. Hence, it is important to take this medication continually unless your doctor tells you otherwise.

The dosage strength and frequency depend on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before taking Provera?

Inform your doctor about all the medications you are taking. Discuss your current and previous medical history and any allergic reactions to Provera or any other ingredients included in the manufacture of this medication.

Ask a pharmacist or respiratory therapist for instructions on using inhalers properly. Pediatric patients should be assisted when administering this medication.

Inform your doctor if you had any form of surgery or if you are planning to get one.

For the drug label information of Provera tablets, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Pain or tenderness felt on the breast
• Hair loss or unwanted hair growth
• Menstrual changes
• Vaginal bleeding or spotting
• Nipple discharge
• Acne
• Sleep disturbance

Serious side effects may include:
• Pain, swelling, redness, tenderness of one leg
• Bulging eyes
• Sudden severe chest pain
• Slurring of speech
• Yellow discoloration of the skin or eyes
• Blisters, hives, itching, or rash
• Swelling of any part of the face or limbs
• Hoarseness, difficulty breathing or swallowing
• Fatigue
• Vision changes
• Problems in memory and cognition
• Mood changes
• Fast or irregular heartbeat

Is it safe to take it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Provera with any of the following medications:

• Acitretin
• Actoplus
• Amprenavir
• Bexarotene
• Biaxin
• Boceprevir
• Bosentan
• Brigatinib
• Carfilzomib
• Coumadin
• Cardizem
• Dabrafenib
• Diflucan
• Encorafenib
• Erythromycin
• Etretinate
• Fosamprenavir
• Glucophage
• Griseofulvin
• Hemin
• Hytone
• Insulin
• Invokana
• Lenalidomide
• Lipitor
• Metaglip
• Mycophenolate mofetil
• Nizoral
• Pexidartinib
• Phenobarbital
• Promalidomide
• Pulmicort
• Rhinocort
• Sporanox
• Sugammadex
• Synthroid
• Telaprevir
• Tranexamic acid
• Vfend

Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Keep Provera in its original packaging in a clean environment away from excessive heat and moisture. Keep out of reach of children.

What action should I take in case of overdose?

Immediately call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

Provera is contraindicated for use in pregnant women, women trying to get pregnant, and breastfeeding women. Hence, the use of Provera in pregnant or breastfeeding infants is not recommended.

It can be excreted in human milk. However, its effects on the infant are still not fully known. Hence, it is essential to consider both the developmental and health benefits of breastfeeding, along with the mother’s clinical need for this medication.

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