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Why is Qulipta prescribed?

Qulipta (Atogepant) is prescribed for the preventative treatment of migraine in adults. It is not used to treat migraines once they occur but is taken daily to help reduce the frequency and severity of migraine episodes.

What does it do?

Qulipta belongs to a class of medications called calcitonin gene-related peptide (CGRP) receptor antagonists, which work by blocking CGRP, a protein involved in migraine attacks. By preventing CGRP from binding to its receptors, Qulipta helps reduce inflammation and pain associated with migraines.

How should I take it?

Qulipta (Atogepant) is an oral tablet taken once daily to help prevent migraine symptoms. You can take it at any time during the day, but maintaining a consistent schedule is recommended. If you experience nausea, taking it with food may help. The usual dosage depends on whether you have episodic or chronic migraine:

• If you have episodic migraine, the usual dose is 10 mg, 30 mg, or 60 mg once per day.
• If you have chronic migraine, the usual dose is 60 mg once per day.

What if I missed a dose?

If you miss a dose of Qulipta, take it as soon as you remember. If your next dose is approaching, skip the missed one and continue following your usual schedule. Avoid taking extra or double doses to compensate for the missed dose.

Keeping a consistent intake schedule helps maximize the effectiveness of the medication. If you find yourself missing doses often, setting a reminder might help.

What are the special precautions before taking Qulipta?

Inform your doctor about all the medications you are taking, your current and previous medical history.

• Avoid taking Qulipta if you have a known allergy to Atogepant or any ingredients of the medication.
• Disclose all your current or past medical conditions to your doctor, particularly if you have kidney or liver disease.
• If you are pregnant or planning to become pregnant, consult your doctor, as its effects on pregnancy are not fully known.
• Do not give this medication to others, even if they have similar condition, as it may pose health risks.
• Watch for any signs of allergic reactions such as hives, swelling, difficulty breathing, or severe dizziness, and seek medical help immediately if these occur.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Fatigue
• Decreased appetite
• Nausea
• Constipation
• Weight loss

Serious side effects may include:
• Elevated liver function tests
• Fast or irregular heartbeat
• Swelling of face, lips, tongue, or throat
• Severe dizziness
• Sudden vision loss or blurred vision

This is not a complete list of all possible side effects, and others may occur. For more information about side effects, please consult your healthcare provider.

Is it safe to take it with another drug?

Qulipta (Atogepant) can interact with various medications, so it's important to check for potential interactions before taking it with another drug. Certain medications can heighten the risk of side effects, while others may lessen Qulipta's effectiveness.

Before taking Qulipta, consult your doctor if you are using any of the following medications:

• Certain antibiotics
• Certain HIV medications
• Cyclosporine
• Certain antifungals
• St. John's wort
• Seizure medications

This is not a complete list of all the potential drug interactions, always consult your doctor or pharmacist before combining Qulipta with other medications to ensure safety.

How should I store it?

Qulipta should be stored in its original container at room temperature, ideally between 20°C and 25°C (68°F and 77°F). Keep it away from direct sunlight and out of reach of children and pets.

What action should I take in case of overdose?

If you believe you have overdosed on Qulipta (Atogepant), seek medical help immediately to ensure prompt and appropriate treatment. Contact emergency services or go to the nearest hospital. Symptoms of an overdose may include severe dizziness, extreme fatigue, or severe nausea.

Is it safe for pregnant or breastfeeding women?

Qtern (Dapagliflozin/Saxagliptin) may not be safe for pregnant or breastfeeding women. Animal studies suggest that Qulipta may cause fetal harm. However, there is limited human data on its effects during pregnancy.

Additionally, it is unknown whether Qulipta passes into breast milk, so if you are breastfeeding, consult your healthcare provider to determine the most suitable feeding options for your baby while using this medication.

If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor about the potential risks and alternative treatments.

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