Why is Samsca prescribed?

Tolvaptan (Samsca) is prescribed in the treatment of hormonal imbalances especially in the regulation of sodium and water in the body. It is given to patients with heart failure and Syndrome of Inappropriate Antidiuretic Hormone (SIADH) to treat hyponatremia.

What does it do?

Vasopressin, an antidiuretic hormone, plays a vital role in regulating the balance of sodium and water in the body. Hence, an imbalance of this hormone may lead to low levels of electrolytes and fluid retention.

Tolvaptan, a selective vasopressin-2 (V2) antagonist, is an aquaretic agent that acts by blocking the vasopressin in the renal collecting ducts, thus, promotes an increase amount of water to be excreted in the urine without affecting electrolyte loss.

How should I take it?

Samsca is available as 15mg tablet. It is intended to be swallowed as a whole, not to be crushed or chewed, and should be taken with or without food intake.

The dosage strength depends on every patient’s condition and the doctor’s prescription. It is strictly advised that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before using Samsca?

Before taking Samsca tablet, tell your doctor or pharmacist if you have any allergies to food and to the drug itself as it may contain several inactive ingredients, which can cause allergic reactions or problems.

It is recommended to have your blood sugar checked regularly as this drug may cause an increase in blood sugar levels. Have a healthy lifestyle and keep hydrated.

Consult your doctor regarding all the other medications you use before getting a surgery.

This medication should not be taken for more than 30 days as it may damage your liver.

For the drug label information of Samsca, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Constipation
• Dehydration
• Dry mouth
• Decreased appetite
• Ear infections
• Fruity breath odor
• Fatigue
• Increased urination

Serious side effects include:
• Black/ bloody stool
• Dark urine
• Difficulty of breathing
• Seizure
• Tachycardia

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Samsca with any of the following medications:

• Aldactone
• Amlodipine + Benazepril
• Aztreonam
• Biaxin
• Bisacodyl
• Carbatrol ER
• Cipro
• Combigan
• Diovan
• Erythromycin
• Itraconazole
• Klacid
• Lioresal
• Lotrel
• Lopinavir
• Micardis
• Nizoral
• Rifadin
• Ritonavir
• Tenormin
• Tramadol
• Zebeta
• Zovirax

If you are using any prescription, non-prescription and herbal medications, inform your doctor and pharmacist for proper information and ask for other possible interactions not listed within this section.

How should I store it?

tore Samsca tablet in room temperature (25 °C) in a clean environment away from light and moisture. Do not remove from the blister if not in use. Keep away from children. Throw away if unused or expired. Do not flush in the toilet. Consult the pharmacist for proper disposal.

What action should I take in case of overdose?

Should an over dosage occur, immediately call an ambulance and seek immediate medical attention to prevent further complications.

Is it safe for pregnant or breastfeeding women?

There are only limited studies and data regarding the safety of Tolvaptan in pregnant women. However, as per USA FDA, Tolvaptan is categorized as Pregnancy Category C. Consult with your doctor and other healthcare provider whether this medication can cause harm to the unborn baby.

The potential presence of Samsca in human lactation is still unknown. Currently, there are no available data on the effects of it on the breastfed child and effects on milk production.

Hence, the use of Samsca in pregnant and breastfeeding women should be avoided unless the potential benefits outweigh the risks.

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