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Why is Sotyktu prescribed?

Sotyktu (Deucravacitinib) is prescribed to treat moderate to severe plaque psoriasis in adults who may benefit from systemic therapy (pills or injections) or phototherapy (UV light treatment).

What does it do?

Sotyktu (Deucravacitinib) is a selective tyrosine kinase 2 (TYK2) inhibitor that works by blocking TYK2, a protein involved in immune system pathways that contribute to inflammation and psoriasis. TYK2 plays a role in activating interleukin (IL)-23 and IL-17, which are key inflammatory cytokines in plaque psoriasis. By inhibiting TYK2, Sotyktu helps reduce inflammation and abnormal skin cell growth, improving psoriasis symptoms.

How should I take it?

Sotyktu should be taken exactly as prescribed by your doctor. Sotyktu is taken once daily as a 6 mg oral tablet, with or without food. The tablet should be swallowed whole without crushing or chewing it. Before starting treatment, patients should be evaluated for tuberculosis (TB) and have their immunizations updated. Sotyktu is not recommended for patients with severe hepatic impairment.

What if I missed a dose?

If you miss a dose of Sotyktu, take it as soon as you remember. If your next dose is approaching, skip the missed one and continue following your usual schedule. Avoid taking extra or double doses to compensate for the missed dose.

What are the special precautions before taking Sotyktu?

Before taking Sotyktu, here are several important precautions to keep in mind:

• Avoid taking Sotyktu if you're allergic to Deucravacitinib, or any of the ingredients in the medication.
• Disclose all your current or past medical conditions to your doctor, particularly if you have:
• Cancer
• Heart problems
• High triglyceride levels
• Blood clot or stroke
• Hepatitis
• Kidney problems
• Liver problems
• Avoid use if you have an active or serious infection, as this medication may increase the risk of serious infections.
• Avoid sharing this medication with others, even if they have a similar condition, as it may cause unexpected health risks or adverse effects.
• If you are pregnant, considering pregnancy, or breastfeeding, consult your doctor to understand the potential risks and benefits of taking this medication.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Acne
• Sinus infection
• Herpes simplex
• Folliculitis (inflamed hair pores)
• Sore throat

Serious side effects may include:
• Cancer
• Severe infections
• Swelling of the face, lips, mouth, tongue, or throat
• Yellowing of skin or eyes (jaundice)

This is not a complete list of potential side effects, and additional reactions may occur. For detailed information and medical guidance, consult your healthcare provider.

Is it safe to take it with another drug?

Sotyktu can interact with various medications, so it's important to check for potential interactions before taking it with another drug. Some interactions may increase side effects or reduce effectiveness.

Before taking Sotyktu, consult your doctor if you are using any of the following medications:

• Blood thinners
• Immunosuppressants
• Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
• Strong CYP3A4 inhibitors
• Statins

This is not a complete list of all the potential drug interactions, always consult your doctor or pharmacist before combining Sotyktu with other medications to ensure safety.

How should I store it?

Sotyktu should be stored in its original container at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

What action should I take in case of overdose?

If you suspect an overdose of Sotyktu (Deucravacitinib), it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital. Overdose symptoms may include nausea, vomiting, dizziness, fatigue, or severe infections.

Is it safe for pregnant or breastfeeding women?

Sotyktu (Deucravacitinib) should be used with caution during pregnancy and breastfeeding. There is limited human data on its safety during pregnancy. Animal studies have not shown evidence of fetal harm, but as a precaution, some authorities recommend avoiding use during pregnancy. For breastfeeding, it is unclear whether Sotyktu passes into human milk, but since it has been detected in animal milk, caution is advised.

If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider for guidance on its use to ensure safety for both you and your baby.

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