Sprycel (Dasatinib) is an oral targeted anticancer treatment used to treat a certain type of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL).

• Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML)
• Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)
What does it do?
The active ingredient in Sprycel is Dasatinib. Dasatinib works by blocking the activity of specific proteins within leukemia cells in patients with chronic myeloid leukaemia (CML) or Philadelphia chromosome positive (Ph+ ALL). These proteins are responsible for the uncontrolled growth of leukemia cells. By inhibiting these proteins, Sprycel helps destroy leukemia cells in the bone marrow, allowing normal production of red blood cells, white blood cells, and platelets to resume.
How should I take it?

Take this medication orally, with or without food. For children the usual starting dose is 100 mg and for adults is it 140mg as prescribed by your doctor typically once a day. Swallow the tablets whole; do not crush, chew, or break them.

The dosage and duration of treatment depends on your medical condition, treatment response, lab results, and any other medications you may be using.

What if I missed a dose?
If you miss a dose of Sprycel, take your next dose at the usual time. Do not take two doses at once. Contact your doctor or pharmacist if you're unsure about what to do.
What are the special precautions before taking Sprycel?

Inform your doctor if you or your child are allergic to any medications, foods, preservatives, or dyes. Let your doctor know if you are breastfeeding or planning to breastfeed. Women taking Sprycel should not breastfeed.

Men taking Sprycel should use a condom to prevent pregnancy in their partner.

Notify your doctor if you or your child have or have had any of the following medical conditions:
• Immune system problems
• Heart conditions
• Liver issues
• Lactose intolerance
• Hepatitis B infection
If you haven't already informed your doctor about any of these conditions, make sure to do so before starting Sprycel.
Does it have any side effects?
It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.
Common side effects may include:
• Diarrhea
• Headache
• Skin rash
• Shortness of breath
• Fatigue
• Nausea
• Muscle pain
For children receiving Sprycel with chemotherapy, the most common side effects include:
• Confusion or disorientation
• Low white blood cell counts with fever
• Fever
• Mucositis
• Nosebleeds
• Numbness or tingling in hands and feet
• Shortness of breath
Serious side effects may include:
• Low Blood Cell Count
• Bleeding Problems
• Fluid Retention
• Cardiovascular Issues
• Pulmonary Arterial Hypertension
These are not all the possible side effects of Sprycel. Let your doctor know if you experience any side effects that concern you or do not go away.
Is it safe to take it with another drug?
It is important to inform your doctor if you or your child are taking any other medications
• Ketoconazole
• Atazanavir
• Erythromycin
• Itraconazole
• Carbamazepine
• Dexamethasone
• Rifampicin
• Cyclosporin
• Warfarin
• Famotidine
Some medications may be affected by Sprycel, or may impact how it works. Your doctor may need to adjust your medication dosages or prescribe different treatments. Always consult with your doctor or pharmacist for more information on medicines to avoid or use with caution while taking Sprycel. Make sure you or your child have a list of all medications and show it to your doctor or pharmacist.
How should I store it?
Keep your tablets in their original pack until it's time to take them. Store the pack in a cool, dry place with a temperature below 30°C.
What action should I take in case of overdose?
If you, your child, or anyone else may have taken too much Sprycel, contact your doctor immediately or go to the nearest emergency department.
Is it safe for pregnant or breastfeeding women?
If you are pregnant or planning to become pregnant. Sprycel can harm your unborn baby.

For females who can become pregnant:

• You should not become pregnant while taking Sprycel.
• Use effective birth control (contraception) during treatment and for 30 days after your last dose of Sprycel.
• Contact your doctor immediately if you become pregnant or suspect you may be pregnant during treatment with Sprycel.
If you are breastfeeding or planning to breastfeed: It is not known if Sprycel passes into breast milk. You should not breastfeed during treatment and for 2 weeks after your last dose of Sprycel.

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