NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Synvisc prescribed?

Synvisc (Hylan) is indicated for the treatment of pain in osteoarthritis of the knee in patients who have failed to achieve adequate relief from conservative nonpharmacologic measures and simple analgesics.

What does it do?

Synvisc is a viscosupplement, an elastoviscous, crosslinked high-molecular-weight hyaluronan fluid derived from chicken combs. When injected into the knee joint, it supplements depleted synovial fluid, restoring lubrication and shock-absorbing properties, which helps reduce pain and improve joint function.

How should I take it?

Synvisc is administered as an intra-articular injection by a trained healthcare professional. The standard regimen consists of 2 mL injected into the knee once a week for three weeks. Before administration, excess synovial fluid should be removed, and strict aseptic technique must be followed.

The product should be used immediately after opening, with any unused portion discarded. Post-injection care includes resting the knee and avoiding high-impact or prolonged weight-bearing activities for at least 48 hours, with icing as a possible aid.

It should be used immediately after opening, with any unused portion discarded. Post-injection care includes resting the knee and avoiding high-impact or prolonged weight-bearing activities for at least 48 hours, with icing as a possible aid.

What if I missed a dose?

If you miss a dosing schedule, call your healthcare provider to reschedule your injection as soon as possible. It’s important to complete the full series (three injections for Synvisc) without undue gaps to maximize pain relief, which can last up to six months.

What are the special precautions before taking Synvisc?

Inform your doctor about all the medications you are taking, your current and previous medical history.

• Do not use if you’re allergic to hyaluronan products, avian proteins (eggs, feathers, poultry), or any component of the device.
• Disclose all your current or past medical conditions to your doctor, particularly if you have blood clots, or an allergy to birds, feathers, or egg products.
• This medication is contraindicated in patients with active knee joint infections or skin infections at the injection site.
• Use cautiously in severely inflamed joints or in legs with venous or lymphatic stasis.
• Avoid skin preps containing quaternary ammonium salts such as benzalkonium chloride, which can precipitate hyaluronan.
• If you are pregnant, considering pregnancy, or breastfeeding, consult your doctor to understand the potential risks and benefits of taking this medication.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Fluid buildup around the knee
• Swelling or stiffness at the injection site
• Muscle pain
• Trouble walking
• Numbness or tingling sensation

Serious side effects may include:
• Back pain
• Difficulty breathing
• Severe pain or swelling around the knee after injection
• Severe headache
• Fast or pounding heartbeat

This is not a complete list of potential side effects, and additional reactions may occur. For detailed information and medical guidance, consult your healthcare provider.

Is it safe to take it with another drug?

Synvisc (Hylan) can interact with various medications, so it's important to check for potential interactions before taking it with another drug. Some interactions may increase side effects or reduce effectiveness.

Before taking Synvisc, consult your doctor if you are using any of the following medications:

• Benzalkonium chloride (topical)
• Cetylpyridinium (topical)

This is not a complete list of all the potential drug interactions, always consult your doctor or pharmacist before combining Synvisc with other medications to ensure safety.

How should I store it?

Synvisc should be stored in its original container at room temperature, ideally between 20°C and 25°C (68°F to 77°F). Keep the medication in a cool, dry place, away from direct sunlight, and ensure it is kept out of reach of children and pets.

What action should I take in case of overdose?

If you suspect an overdose of Synvisc (Hylan), it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital. Overdose symptoms may include severe joint pain, swelling, stiffness, or fluid buildup in the knee.

Is it safe for pregnant or breastfeeding women?

The safety of Synvisc (Hylan) for pregnant and breastfeeding women has not been established. It is unknown whether Synvisc can cause fetal harm or affect reproductive capacity. Since there is no definitive safety data, pregnant or breastfeeding women should consult their healthcare provider to weigh the potential risks and benefits before receiving Synvisc injections.

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