Vumerity is prescribed for the treatment of adults diagnosed with relapsing types of multiple sclerosis, encompassing clinically isolated syndrome, relapsing-remitting multiple sclerosis, and active secondary progressive multiple sclerosis.

What does it do?

The exact mechanism of action of Vumerity is not fully understood, but it is believed to influence how cells respond to oxidative stress and inflammation, potentially reducing immune-mediated damage to the nervous system.

How should I take it?

Vumerity should be taken as directed, starting with one capsule (231 mg) twice daily for the first seven days, then increasing to two capsules (462 mg) twice daily. Capsules must be swallowed whole and should not be crushed, chewed, or opened. If taken with food, avoid meals or snacks that exceed 700 calories or 30 grams of fat, and alcohol should be avoided during treatment. It is important to follow your doctor’s instructions and attend regular blood tests to monitor safety.

What if I missed a dose?

If a dose of Vumerity is missed, take it as soon as you remember, unless it's already close to the time for your next scheduled dose. In that case, simply skip the missed dose and continue with your regular dosing routine. Avoid taking additional or double doses, as this can increase the risk of adverse effects.

What are the special precautions before taking Vumerity?

Inform your doctor about all the medications you are taking, your current and previous medical history.Before taking Vumerity, here are several important precautions to keep in mind:

• Do not take Vumerity if you're allergic to Diroximel Fumarate, Dimethyl Fumarate, or any of the ingredients in the medication.
• Monitor for Anaphylaxis and Angioedema during treatment
• Disclose all your current or past medical conditions to your doctor, particularly if you have:
• Liver problems
• Kidney problems
• Infections
• Low white blood cell (WBC) counts
• Your healthcare provider will perform blood tests both before starting Vumerity and periodically throughout your treatment.
• Avoid sharing Vumerity with others even if their condition appears similar, as doing so may result in unexpected health risks or dangerous side effects.
• Talk to your doctor before taking this medicine if you are pregnant, planning to become pregnant, or breastfeeding. Your doctor can help you weigh the potential benefits and risks for both you and your baby.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Flushing
• Nausea
• Diarrhea
• Stomach pain
• Skin rash

Serious side effects may include:
• Difficulty breathing
• Progressive multifocal leukoencephalopathy (PML)
• Yellowing of the skin or eyes (jaundice)
• Gastrointestinal complications
• Severe infections

This is not a complete list of potential side effects, and additional reactions may occur. For detailed information and medical guidance, consult your healthcare provider.

Is it safe to take it with another drug?

Vumerity (Diroximel Fumarate) has the potential to interact with a wide range of medications, which can either heighten the risk of side effects or diminish its therapeutic effectiveness.

Before taking Vumerity, consult your doctor if you are using any of the following medications:

• Dimethyl fumarate (Tecfidera)
• Aspirin
• Adalimumab
• Baricitinib
• Fexinidazole
• Pexidartinib

This is not a full list of possible drug interactions. To ensure your safety, it's essential to speak with your doctor or pharmacist before taking Vumerity alongside other medications.

How should I store it?

Vumerity should be kept in its original container and stored at room temperature, ideally between 20°C and 25°C (68°F to 77°F), to maintain its effectiveness. Be sure to protect it from excess heat, moisture, and light, and keep it out of reach of children and pets.

What action should I take in case of overdose?

In case of a Vumerity (Diroximel Fumarate) overdose, you should seek immediate medical attention by contacting your local emergency services or going to the nearest hospital. Overdose symptoms may include severe flushing, gastrointestinal distress, difficulty breathing, swelling of the throat or tongue, vision problems, or weakness on one side of the body.

Is it safe for pregnant or breastfeeding women?

Vumerity (Diroximel Fumarate) is not recommended during pregnancy unless the potential benefits clearly outweigh the potential risks to the fetus, as there are no adequate human studies confirming its safety. It is also unknown whether Vumerity is excreted in human breast milk.

Therefore, caution is advised, and healthcare providers should carefully evaluate the risks and benefits before prescribing it to breastfeeding women. Women who are pregnant, planning to become pregnant, or currently breastfeeding should consult their physician to determine the most appropriate and safe treatment options.

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