NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Ziac prescribed?

Ziac (Bisoprolol/ Hydrochlorothiazide) is a combination medication containing hydrochlorothiazide, a thiazide diuretic, and bisoprolol, a beta-blocker, used to treat high blood pressure (hypertension).

What does it do?

Bisoprolol/Hydrochlorothiazide lowers blood pressure by blocking beta-1 receptors in the heart, which slows the heart rate, and by increasing urination to help remove excess sodium and water from the body. It also relaxes blood vessels, allowing for better blood flow, which can reduce the risk of heart attack and stroke.

How should I take it?

Take this medication orally, following the directions on the prescription label, and at the same time each day. Continue taking it unless your doctor advises you to stop.

What if I missed a dose?

If you miss a dose of Ziac, take it as soon as you remember. However, if it is close to the time for your next dose, omit the missed dose and take only the scheduled dose. Do not double dose.

What are the special precautions before taking Ziac?

Inform your doctor about all the medications you are taking, your current and previous medical history. To ensure Ziac is safe for you, inform your doctor if you have:

• Diabetes
• Glaucoma
• Kidney disease
• A thyroid disorder
• An allergy to sulfa drugs or Penicillin
• Lupus Congestive heart failure
• Liver disease (or cirrhosis)
• Difficulty urinating
• Severe or uncontrolled heart failure
• Asthma or other respiratory conditions
• Peripheral vascular disease (e.g., Raynaud's syndrome)

Ziac is not recommended for use in individuals under 18 years of age.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Contact your doctor immediately if you experience any of the following:

• Chest pain
• Slow, fast, or irregular heartbeats
• Shortness of breath (even with mild activity), swelling, or rapid weight gain
• Liver issues, including dark urine, clay-colored stools, upper stomach pain, or yellowing of the skin or eyes
• Low blood sugar symptoms, including hunger, sweating, dizziness, fast heart rate, and anxiety or shakiness
• Signs of an electrolyte imbalance, such as increased thirst or urination, irregular heartbeats, chest fluttering, or a choking sensation

Common side effects may include:
• Cough
• Headache
• Diarrhea, nausea, or indigestion
• Dizziness
• Weakness or fatigue

This is not a complete list of side effects, contact your doctor for medical advice regarding any side effects.

Is it safe to take it with another drug?

Notify your doctor of all other medications you are currently taking including vitamins, prescription and over-the-counter medications, and herbal supplements, especially:

• Lithium
• Colestipol or cholestyramine
• Sedatives or narcotic medications
• Insulin or oral diabetes medications
• Heart or blood pressure medications, such as Diltiazem, Digoxin, Disopyramide, and others
• NSAIDs (nonsteroidal anti-inflammatory drugs) like Aspirin, Ibuprofen
• Steroid medications, including Prednisone and others

This is not a fully inclusive list; it is important to consult your doctor before starting this medication.

How should I store it?

Store Ziac at room temperature, away from heat and moisture.

What action should I take in case of overdose?

If you suspect you have taken too much Ziac, immediately contact your doctor or go to the nearest emergency department. Symptoms of an overdose may include leg cramps, confusion, numbness and slow heart rate, tingling, or fainting.

Is it safe for pregnant or breastfeeding women?

It is not known if Bisoprolol/Hydrochlorothiazide can affect pregnancy or harm an unborn baby. Consult your doctor if you are pregnant or planning to become pregnant for guidance on whether to take this medication.

Hydrochlorothiazide, one of the active ingredients, can pass into breast milk, but it is unclear if Bisoprolol does. Inform your doctor if you are breastfeeding or plan to breastfeed, and follow their advice on whether to continue breastfeeding or stop taking Bisoprolol/Hydrochlorothiazide.

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