NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Zoryve Cream prescribed?

Zoryve cream (Roflumilast) is used to treat plaque psoriasis and atopic dermatitis.

What does it do?

Zoryve works by blocking the enzyme PDE4, which helps lower inflammation and relieve symptoms associated with plaque psoriasis and seborrheic dermatitis. Its active ingredient, roflumilast, is part of a class of medications known as phosphodiesterase-4 (PDE4) inhibitors.

Why is Zoryve Cream prescribed?

Zoryve cream is for external use only—do not swallow it. Wash your hands before and after using Zoryve cream. If you’re using it on your hands, wash prior to application only.

What if I missed a dose?

If you miss a dose of Zoryve cream, apply it as soon as you remember. However, if it’s nearly time for your next scheduled application, use only that dose. Do not apply extra or double doses.

What are the special precautions before taking Zoryve Cream?

Inform your doctor about all the medications you are taking, your current and previous medical history.

Before starting Zoryve cream, inform your doctor about all your medical conditions, including if you:

• Have liver problems: Do not use Zoryve cream if you have certain liver conditions.
• Are pregnant or planning to become pregnant, as it is unknown whether Zoryve cream may harm your unborn baby.
• Are breastfeeding or planning to breastfeed, since it is unclear if Zoryve cream passes into breast milk. Discuss the best feeding options with your healthcare provider during treatment.

If you are breastfeeding and using Zoryve cream, apply it to the smallest possible skin area for the shortest duration necessary. It is advisable to refrain from applying the cream to the nipple or areola to prevent any potential contact with the baby.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:

Common side effects of Zoryve cream for plaque psoriasis:

• Nausea
• Diarrhea
• Difficulty sleeping
• Urinary tract infections (UTIs)
• Upper respiratory tract infections

For those using Zoryve cream to treat atopic dermatitis, common side effects include:

• Application site pain
• Headache
• Diarrhea
• Nausea
• Vomiting

This list does not include all potential side effects of Zoryve cream. Please consult your doctor before starting the medication, as other side effects may arise.

Is it safe to take it with another drug?

Some drug interactions may cause serious or life-threatening reactions when administered together. Immediately inform your doctor if you are taking Zoryve cream with any of the following medications:

• Birth control pills
• Erythromycin
• Cimetidine
• Fluvoxamine
• Ketoconazole

This is not a complete list of possible interactions. Be sure to provide your doctor with a full list of all medications, herbal products, over-the-counter drugs, and dietary supplements you are taking.

How should I store it?

Store Zoryve cream at room temperature (68°F to 77°F / 20°C to 25°C) and keep it, along with all medications, out of the reach of children.

What action should I take in case of overdose?

If you have used too much Zoryve cream, go to the nearest emergency department immediately for consultation.

Is it safe for pregnant or breastfeeding women?

Pregnancy: It is unknown whether Zoryve affects pregnancy or poses a risk to an unborn baby. Inform your doctor if you are pregnant or planning to become pregnant.

Breastfeeding: It is unknown whether Zoryve passes into breast milk. Inform your doctor if you are breastfeeding, so they can advise you on whether to use Zoryve. If breastfeeding while using Zoryve, avoid applying it to the nipple or areola and ensure treated chest skin does not come into direct contact with the baby.

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